Patient Specific Implants

The customized implant has opened up a new horizon for the next generation of prostheses and implants. These scaffolds are designed and manufactured according to the dimensions, geometry and mechanical properties required by each patient. 3D printing technologies not only enable the personalization of implantable devices with respect to patient-specific anatomy, pathology and biomechanical properties but they also provide new opportunities in related areas such as surgical education, minimally invasive diagnosis, medical research and disease models.

3Dbioprinting is a process of making 3 dimensional objects from a digital file. Precise data acquisition for the accurate production of personalized scaffolds is done using CT or magnetic resonance imaging (MRI) image datasets. Scaffolds are produced based on computer-aided design/ computer-aided manufacturing (CAD/CAM). Finally, biological materials, biochemicals and living cells are printed layer by layer similar to the lost tissue to create a 3D structure.

References:

Rasperini, G., Pilipchuk, S. P., Flanagan, C. L., Park, C. H., Pagni, G., Hollister, S. J., & Giannobile, W. V. (2015). 3D-printed bioresorbable scaffold for periodontal repair. Journal of dental research, 94(9_suppl), 153S-157S.

Teo, L., Teoh, S. H., Liu, Y., Lim, L., Tan, B., Schantz, J. T., & Seah, L. L. (2015). A novel bioresorbable implant for repair of orbital floor fractures. Orbit, 34(4), 192-200.

Park, Y. J., Cha, J. H., Bang, S. I., & Kim, S. Y. (2019). Clinical application of three-dimensionally printed biomaterial polycaprolactone (PCL) in augmentation rhinoplasty. Aesthetic plastic surgery, 43, 437-446.

Korn, P., Ahlfeld, T., Lahmeyer, F., Kilian, D., Sembdner, P., Stelzer, R., … & Gelinsky, M. (2020). 3D printing of bone grafts for cleft alveolar osteoplasty–in vivo evaluation in a preclinical model. Frontiers in bioengineering and biotechnology, 8, 217.

Schantz, J. T., Lim, T. C., Ning, C., Teoh, S. H., Tan, K. C., Wang, S. C., & Hutmacher, D. W. (2006). Cranioplasty after trephination using a novel biodegradable burr hole cover: technical case report. Operative Neurosurgery, 58(1), ONS-E176.

Probst, F. A., Hutmacher, D. W., Müller, D. F., Machens, H. G., & Schantz, J. T. (2010). Calvarial reconstruction by customized bioactive implant. Handchirurgie, Mikrochirurgie, Plastische Chirurgie: Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie: Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse: Organ der V…, 42(6), 369-373.

Patient Specific Implants

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